He was the protected rider for Dimension Data but a crash at 4km saw Renshaw hit the deck along with teammates Youcef Reguigui and Jay Thomson.
While Reguigui and Thomson could finish the race, it was clear Renshaw would be unable to continue.
“Mark will undergo surgery because of a fractured Talus bone in his right ankle,” said team doctor Dirk Tenner.
“The surgery will be done in Cologne and he will spend two additional nights in hospital under observation before being able to return home.
“Without any complications, we expect that Mark will be able to start training in two weeks.”