Porte, who rides for BMC Racing, crashed in the bunch less than 10km into the stage. He reportedly broke his collarbone as a result.
The Australian last year also crashed out of the French Grand Tour in stage nine when he hit a rock wall on a descent.
Porte recently won the Tour de Suisse, a race depicted as one of the major “trial” events in the build up to the Tour de France. He headed into the stage 10th on the general classification standings.